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This is particularly important in smokers due to decreased tissue perfusion

Gabapentin addiction develops when: The drug is taken at higher-than-prescribed doses Its used more frequently than prescribed Its combined with other substances (especially opioids or alcohol) The person has a history of substance use disorder Medical use at prescribed doses carries a lower addiction risk but can still lead to physical dependence

While not oral, a patch can provide a steady dose of nicotine through your skin over several hours

PLoS Genet 2008

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doi: 10.1016/s0954-6111(12)70011-2 34