Under normal conditions the plasmodesmata is too small for the whole TMV complex to pass through, but when bound to the movement proteins the plasmodesmata expands its diameter and allows the TMV virion to pass through the junction and infect the neighboring cell.[5] This process is repeated for cell-to-cell infection, but once the virus particles reach the plants phloem, the vascular tissue in plants, the infection becomes systemic, spreading from the roots to the leaves.[5] Epidemiology Viruses need to have a host organism in order to continue having progeny and passing on their genetic code, TMV is no different
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Lewisohn 2002, p
Furthermore, multivariable MR allows for the simultaneous estimation of the independent and joint effects of two or more exposures on an outcome 18 , which is particularly relevant given that the combined exposure to tobacco and alcohol has been demonstrated to exert a significant synergistic effect on the incidence of HNSCC 19
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For e-cigarettes, companies would also have to provide information such as e-liquid volume, battery capacity and wattage
