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One study found that people with insomnia have an average of 30% less GABA in their brains than those without, suggesting that supplementation might alleviate their symptoms.20 Vitamins and minerals Among vitamins and minerals, B6, B12, and magnesium are the three you should have your eye on, as a 2019 study found that people with moderate insomnia saw symptom improvement after three months of supplementation with these nutrients (alongside melatonin).22 We especially like magnesium (enough to write a whole guide to magnesium-based sleep supplements) since it can also lower your cortisol levels, which are stress-linked and highest upon waking.23 Complex Supplements There are some good complex supplements out there that thoughtfully combine clinical doses of multiple botanicals, vitamins, minerals, and other components