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Unfortunately, these flavor chemicals are not regulated, and some can be significantly toxic

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Non-tobacco users comprised 59% of the sample and make up an even larger share of the U.S

We developed a search string to search for studies reporting any association between binary smoking status (that is, current, former and ever smokers) and the five CVD outcomes from 1 January 1970 to 31 May 2022, and included only studies reporting age-specific risk (RR, odds ratio (OR), hazard ratio (HR)) of smoking status

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[4] The documentary premiered to the public in the widest documentary opening ever, screening at over 1,000 venues on April 20, 2008