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Diethylstilbestrol (DES), a synthetic estrogen advertised from 1941 to 1971 as a treatment during pregnancy to prevent miscarriages, was found to cause genital cancers in offspring

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Some people carry one or two copies of a genetic variant, which is associated with heavier tobacco use

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This method does mean that you are at risk from heavy metals such as lead, cadmium and arsenic, and other substances that the tobacco plant pulls out of the ground (6)