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Cotinine has a half-life of about 16 hours, according to the Centers for Disease Control and Prevention (CDC)

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CONCLUSIONS The common population-attributable risk factors for acute coronary syndrome (ACS) in the southwestern region of Saudi Arabia include cigarette smoking, waterpipe smoking, hypertension, diabetes mellitus, hypercholesterolemia, central obesity, khat chewing, and a family history of myocardial infarction (MI)

Nationally, lifetime PCP use among individuals aged 12 and older was about 2.1% in 2023, down from 2.3% in prior years, with an estimated 5.9 million people reporting lifetime use, according to the Drug Enforcement Administration (2025)