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The reverse is also true: pain from serious heart conditions may be confused with ulcer pain and not addressed properly

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These drugs strongly stimulate the brain's reward system, create intense cravings, and produce rapid tolerance, making them extremely difficult to quit without medical or behavioral support

Their sturdier structure and even burn make them more reliable for longer sessions

Some states in the US and Canada have been developing harm-reduction strategies, guidelines and protocols in response to an increasing demand related to the regulation of cannabis use (Borodovsky et al., 2022