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Acknowledgements We thank Fasteris SA (Geneva, Switzerland) for the construction of some mate-pair libraries and the PMI R&D High Performance Computing team for making the computational work possible

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Common effects include: Increased heart rate and blood pressure Narrowing of blood vessels Increased risk of heart disease and stroke Strong addiction that makes quitting difficult How Nicotine Affects People Living With Diabetes For people living with diabetes, nicotine can make daily management harder and increase long-term risks

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