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BP and HR changes were compared among (1) different study groups (users of high, low, and zero nicotine products) and (2) pooled continuous smoking phenotype classification (same phenotype from week 12 to -52), with participants classified as quitters (completely quit smoking), reducers (50 % reduction in smoking consumption) and failures ( 45 years old) have d higher systolic (but not diastolic) BP compared to non-smokers when adjusted for age, body mass index, social class, and alcohol intake [9]
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Indeed, third-generation devices with lower nicotine concentrations and higher wattage resulted in greater nicotine plasma levels than second-generation products containing higher nicotine concentrations and lower wattage [15]
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Second, the diversity of subpopulations of TNP users sampled in the studies provided a broad frame of reference that demonstrated the validity of the measure
