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Some of these conditions can be fatal and cause irreversible damage

While cigarillos can be inhaled, deep inhalation may increase nicotine absorption and exposure to harmful chemicals, which is why they are traditionally puffed rather than smoked like cigarettes

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Exposure to 9 -tetrahydrocannabinol (THC) increases subsequent heroin taking but not heroin's reinforcing efficacy: a self-administration study in rats

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