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Because it recommends that inhaled corticosteroids or other drugs with similar effects be administered early in the natural course of COPD, this not only inhibits airway inflammation, but may also inhibit epithelial activation, EMT, and associated fibrosis and malignant consequences

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Phantosmia may indicate an underlying medical condition, which could range from mild to moderate, such as sinusitis, to severe, including brain tumors or neurological disorders

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A dose-response relationship is usually considered to be evidence for supporting causality