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Moreover, in quasi-experimental studies, the non-random allocation of study participants may result in residual confounding, potentially biasing the estimation of policy effects 521

79 In addition to increasing the risk of developing gastrointestinal reflux disease, animal studies show that cigarette smoke can accelerate the damage done by gastrointestinal reflux disease, which is especially concerning since it increases the risk of a precancerous condition called Barretts esophagus

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