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CS, E-cigs, and breast cancer In the US, it has been estimated that 16% of all adults are classified as smokers, 10,11 and therefore, CS persists as the largest preventable cause of death

Wound healing problems and skin loss are six times more likely for smokers than for non-smokers

Although the insulas role in interoceptive monitoring has been well characterized [80] and higher nAChR availability in the thalamus, PFC, and cerebellum has been positively correlated with increased pain sensitivity among abstinent smokers [96], relatively little neuroimaging work has focused on the neurobiological processes that may contribute to smoking- or withdrawal-related pain dysregulation

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