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Modern nose-only exposure tubes that allow body heat to dissipate are regarded by some as superior to whole-body exposure chambers because they eliminate dosing by nonrespiratory routes and allow the test concentration delivered to the animal to be closer to the concentration delivered to the system, by avoiding loss of the test compound on the walls, loss on the skin and fur of the animals, sedimentation and impaction of aerosol particles in the chamber, and chemical reactivity in the chamber (Pauluhn 2005)

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The measure of TTFC is factored as a core item in the FTND, and Heaviness of Smoking Index (HSI), which are the widely used global instruments 9