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One refill fluid contained cinnamaldehyde at ~34% (343 mg/ml), more than 100,000 times its cytotoxic level

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Sensitivity analyses showed that participants who died within a short period of time had little effect on the results of the Cox proportional regression model and the multivariable RCS model, suggesting that the correlation between folate/vitamin b12 and mortality was not confounded by reverse causal effects ( Supplementary Table S1 , Supplementary Figure S1 )