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Shepperd CJ, Newland N, Eldridge A, Graff D, Meyer I: A single-blinded, single-centre, controlled study in healthy adult smokers to identify the effects of a reduced toxicant prototype cigarette on biomarkers of exposure and of biological effect versus commercial cigarettes

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However in the past, pipe smoking used to be the only choice, in fact, it wasn't until the early part of the 20th Century that roll your own and prepacked cigarettes became increasingly available, cost-effective and popular

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