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Chronic exposure to tobacco smoke or nicotine leads to tolerance to the physiological (e.g., decrease in heart rate and body temperature) and behavioral (e.g., decrease in locomotor activity and rearing) effects of nicotine and an upregulation of 42 and 7-containing nAChRs in rats and mice (Pauly et al., 1991
Whitish mucosal lesions were observed on the palate, particularly near the maxillary molar palatal surfaces, indicating increased keratinisation and can also be attributed to nicotine consumption
It should also be noted that participants had few or no adverse reactions to the studies, though some had headaches
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