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Future research to identify other susceptibility factors, such as genes that modify carcinogen metabolism or DNA repair, will need to be substantially larger and to quantify lifetime tobacco exposure with more precision than have past studies in order to distinguish gradations in risk due to exposure from those caused by genetic susceptibility
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using a wide variety of media channels and approaches that have been used in the past for marketing conventional tobacco products to youth and young adults. 16 In fact, 20.5 million youth (or 78.2% of middle and high school students) reported being exposed to e-cigarette advertisements from at least one source, according to the 2016 National Youth Tobacco Survey, an increase from 68.9% in 2014
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