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The greater the pack years, the more likely the lungs will have irreversible damage, he noted

Cigarette smoke differently alters normal and ovalbumin-sensitized bronchial epithelial cells from rat

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Consequently, male smoking-attributable mortality is likely to remain (or become again) higher than female smoking-attributable mortality

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that is, they are greater than would be expected from adding the individual harms associated with alcohol and tobacco together (25, 26)