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Verpoort KN, Papendrecht-van der Voort EA, Helm-van Mil van der AH, Jol-van der Zijde CM, van Tol MJ, Drijfhout JW, Breedveld FC, de Vries RR, Huizinga TW, Toes RE: Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles

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According to research in the National Center for Biotechnology Information (NCBI), they contain a median of 102 g of nicotine per kg