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At intervals, a narrator has broken the "fourth wall," addressing the audience directly, explaining, as if he is the narrator of a travelogue, the ways of the folks of Borgo San Giuliano, and what threads and strands of meaning make up the tapestry of their lives

Young people are particularly vulnerable to addiction, and with high rates of cessation remaining elusive worldwide, the tobacco epidemic will continue for years to come unless countries can dramatically reduce the number of new smokers starting each year, Reitsma told The Guardian

He had a myriad of passengers who were smokers

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However, after injection of LPS to stimulate an immune response, the neuroimmune response was significantly reduced in the striatum and cortex of smokers compared to non-smokers