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Nicotine and Cotinine

[100] From the moment COHb levels reach 4.3%, VO2maxdecreases in accordance with the following equation: VO2max = 0.91(%COHb) + 2.2 Conclusions Smoking, through its basic ingredients nicotine and CO, increases oxidative stress, endothelial damage and dysfunction, is associated with significantly higher serum concentrations of total cholesterol and triglycerides, reduces the cardioprotective HDL, and by promoting intravascular inflammation represents a significant risk factor for the development of atherosclerosis and cardiovascular disease

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Mar Pollut Bull 174:113310

Cardiovascular workouts like power walking, aerobics, jogging, or cycling are particularly good because they involve moving the entire body, which favors proper peristalsis