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As a neuroprotective mechanism, the NKCC activity at the BBB basolateral side increases during ischemia as it is phosphorylated by protein kinase C (PKC) to remove excess potassium from the brain (Yerby et al., 1997

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When oxygen supply to the gum tissues decreases, the gums may lose their pink color and appear pale or white

It impairs the healing process in the mouth, making it harder for gum tissue to recover from damage or dental procedures, resulting in a receding gum line

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