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Retrieved December 11, 2020, from HERE 4

When the central repressors of ferroptosis, such as glutathione (GSH) and lipid enzyme glutathione peroxidase 4 (GPX4) [103], which participate in peroxide reduction and reduce product toxicity, show insufficient activity, the lipid radicals formed cannot be cleared and continue to generate new oxidative products via chain reaction

Elvira De Leonibus, National Research Council (CNR), Italy Updates Copyright 2020 Wen, Aki, Unuma and Uemura

But what does this mean for those in the lab

Chong Hyun Won

There is a growing recognition of the importance of glutathione (GSH) physiology and the number of physiological functions involving this small but important tripeptide