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The authors hypothesized that oxidative degradation of nicotine during the manufacturing of the ingredient or of the final liquids, interactions with packaging material, inadequate handling and storage, or an unstable formulation could have resulted in the high amounts of nicotine-related impurities measured

a small volume of liquid butane expands into hundreds of times that volume of flammable vapor once the pressure is released

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The maps recommended by the authors are listed below

SAGA TPD 2024 PRODUCT SUITE Implement PSQRs off-the-shelf solution for compliance with the Tobacco Products Directive (TPD) for other tobacco products (OTP)

S2CID 19915646