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Bradford Hill British Medical Journal 1950 (volume two), pages 740-748 September 30, 1950 In England and Wales the phenomenal increase in the number of deaths attributed to cancer of the lung provides one of the most striking changes in the pattern of mortality recorded by the Registrar-General

If we assume that the parents of the 4 cases described here are asymptomatic heterozygous carriers, the probability of each couple having a child with KS is 25% per pregnancy,3 hence the importance of providing patients and their parents with genetic counseling

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