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In practice, nicotine substitutes often refer to tobacco substitutes: an alternative that contains no tobacco or nicotine

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Cigarettes contain nicotine, which is a powerful addictive substance in its own right

Related: E-cigarette ads target kids, CDC says And, the FDA noted, "the health benefit of reducing cigarette consumption instead of quitting completely is unclear." Public health researcher Noel Brewer of the University of North Carolina led a team that also questioned the application

This includes discussing STD test status and history, especially when starting a sexual relationship