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Smoking habits, like inhalation depth and puff frequency, also impact nicotine intake

Without prospective longitudinal research, questions remain about whether early e-cigarette use leads to lasting decrements in spirometry indices or exercise performance later in life

Efficacy end points were analysed with logistic regression models with terms for study centre and treatment group

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There is also a lack of detail on power calculations or effect size assumptions, limiting the significance of these findings