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E-cigarettes can lead to changes in gene expression within lung immune and structural cells, reducing innate and adaptive immune defenses in the lungs and increasing susceptibility to infections
Similarly, the HRs of heavy smoking were 16.22 (10.9723.97), 17.06 (13.9720.84) and 21.22 (15.3429.35) compared with no smoking
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17 Furthermore, in a model of inhalational tolerance, prolonged cigarette smoke exposure of mice significantly delayed the establishment of tolerance induced by repeated harmless antigen challenges
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