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[50] These derivatives can cause depurination, the removal of bases from the phosphodiester backbone of DNA, followed by inaccurate repair or replication of the apurinic site leading to mutation and eventually cancer

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Also, when you smoke it, your breath becomes very bad.[9] As with all cigarettes, after smoking, the mucous membrane in the mouth dries and saliva production decreases, causing bad breath

Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional study