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On the other end of the spectrum, there are some who smoke cigarettes on occasion, which often gets a pass as being not as bad. But light smoking, despite the lower daily cigarette consumption, still has health implications

88 Nicotine itself increases the likelihood of another painful condition, gastrointestinal reflux disease (GERD), because it relaxes the sphincter muscle at the lower end of the esophagus

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We also found that the interaction between PlexinB1 and RhoA was enhanced by Sema4D stimulation (Fig