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In 52 global controlled and uncontrolled clinical trials of HUMIRA in adult subjects with RA, PsA, AS, CD, UC, Ps, HS and UV with a median duration of approximately 0.7 years, including 24,605 subjects and over 40,215 patient-years of HUMIRA, the observed rate of lymphomas was approximately 0.11 per 100 patient-years

Two randomized trials examined individuals who switched from tobacco cigarettes to electronic cigarettes, revealing that using ECs for 5 days did not lead to negative respiratory health outcomes, with spirometry findings showing no significant effect on airflow obstruction or lung function after EC use (32)