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This, in turn, results in a decrease in pyrimidine nucleotide availability, halting the purine-pyrimidine pairing process and ultimately impeding RNA synthesis (50)

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e) New Checkpoint Inhibitors: Beyond PD-1 and CTLA-4 inhibitors, researchers are developing novel checkpoint inhibitors targeting other immune checkpoints

10.3389/fcell.2022.810327 187 HuX.BaoY.LiM.ZhangW.ChenC