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The sudden absence of nicotine causes dopamine to drop sharply, triggering the strongest cravings, the worst mood disruption, and the most uncomfortable physical symptoms

1 PRISMA 2020 flow diagram for an updated systematic review of the Smoking and Tracheal, bronchus, and lung cancer risk-outcome pair

Hum Mol Genet 11:569576 Haq I, Lowrey GE, Kalsheker N, Johnson SR (2011) Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD

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However, this artificial reward system becomes addictive quickly, leading the brain to depend on nicotine to feel "normal." Why This Matters: Nicotine is not treating the root cause of ADHD

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