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Progressive and more serious symptoms include bleeding gingiva to gentle stimulation, severe discomfort with eating or swallowing, interproximal crater-like ulcers, tissue destruction around the teeth, swollen head and neck lymph nodes, and mild fever and fatigue

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The median number of cigarettes smoked per day ranged from 0.03 in Qazvin to 20 in Kermanshah, Gilan, Lorestan, and Fars