The toxic dose of nicotine for adults is around 50-60 mg, but nicotine poisoning can start at much lower levels, especially in individuals who have a lower tolerance or are new to nicotine use
However, caution is required in interpreting these results, as this perceivable benefit was accompanied with a significant elevation in liver enzymes, thus establishing these apparently beneficial changes as a mere reflection of the toxic damage of electronic cigarette liquid on the liver.94 Recently, electronic cigarettes have been proposed as a possible interfering factor in the splenocardiac axis, a signalling network involving the brain, autonomic nervous system and hematopoietic tissues
Analytical and toxicological evaluation of flavor chemicals in electronic cigarette refill fluids
Heartburn is usually worse after eating
doi:10.1080/20009666.2020.1800978
Only about 1 in 5 women had low levels of red blood cell folate concentrations, Wang said