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Dependence and Withdrawal: Long-term use leads to severe dependence and withdrawal symptoms, such as fatigue, irritability, and cravings, which complicate cessation efforts

[17] Your doctor will have you increase your dose over time

[117] found that renal dysfunction was linked to CS-induced lung injury, with an association between emphysema severity and the estimated glomerular filtration rate

Quality assessment Quality assessment of individual studies was completed independently by two reviewers, and any disagreements were resolved by discussion between the reviewers

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