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Since the lower esophageal sphincter is composed of smooth muscle, the intake of nicotine during smoking can cause the muscle to relax and function improperly

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Study 2, nicotine pharmacokinetics The four 1.8% nicotine concentration flavor variants (Alto Rich Tobacco, Golden Tobacco, Menthol and Mixed Berry) and the 2.4% nicotine concentration Golden Tobacco flavored Vuse Alto products displayed generally similar PK profiles and nicotine uptake parameters with overlaps of 95% CI (Fig

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10, 11 and 14, 2023