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If oral mucosal changes were present, the changes were photographed (Canon, EOS 80D, Oita, Japan), and samples of the mucosal tissue were collected

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The evaluated biomarkers included cotinine (in urine, plasma, and saliva), tobacco-specific nitrosamines (NNAL and NAT), and inflammatory markers (IL-6 and IL-1) in saliva (Supplementary Table S2)