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1964), combined with observational studies showing the association between emphysema and deficiency of 1-antitrypsin (AAT) (Laurell and Eriksson 1963), led naturally to the hypothesis that the pathogenesis of emphysema was based on a functional proteolytic imbalance within the inflammatory response induced by tobacco smoke(Gadek et al

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As the recent death of Hall of Fame outfielder Tony Gwynn has reminded us, smokeless tobacco can be a killer, Durbin said in a recent news release from his office

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