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Weaker immune system A body with a weak immune system leads to slower healing wounds and increases likelihood of infection and illness

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Recent studies also suggest that nicotine-containing e-cig aerosol exposures acutely delay ventricular repolarization in humans 19 while chronically inducing systolic dysfunction and atherosclerosis in a mouse model of atherogenesis 20

Substance use phenotypes As ascertaining large numbers of individuals with a diagnosed SUD is challenging, many studies have focused on broader, use-based phenotypes such as initiation, frequency, or quantity of use, which are easily assessed in large-scale cohorts and biobanks

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