This suggests that people who smoke may do so to increase their overall brain connectivity with the stimulating effect of nicotine
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[127] [128] The pharmacological, metabolic, and toxicological effects of (R)-nicotine and of racemic (R)/(S)-nicotine mixtures in humans remain poorly understood, with data largely limited to animal studies
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From the 1950s through the early 1980s, national public health institutions and voluntary organizations supported the idea of tobacco harm reduction