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Earlier in the 2008, in PC-3M prostate cancer cells, -CBT-diol has been proven to inhibit cell invasion in Matrigel assay, through reducing transepithelial resistance, enhancing paracellular permeability, producing a tighter intercellular barrier and enhancing the cell-cell adhesion ( In vivo , -CBT-diol inhibited PC-3M cells locoregional recurrences after primary tumor surgical excision and tumor distant recurrence, and reduced the levels of plasma kynurenine and the recurrence protein marker PSA in mice ( 4.2 Neuroprotective effect In the past 20 years from the year 20012022, the study on the neuroprotective effects of cembranoids has not stopped ( -CBT-diol also decreased brain damage in rodent ischemic stroke models ( -CBT-diol improved Parkinsons disease both in vitro neuro-2a cell models and in vivo rat models induced by 6-Hydroxydopamine challenge ( The most recent study in the year of 2022 reported that -CBT-diol protected neuronal cells from oxygen-glucose deprivation by modulating microglial cell activation ( in vivo , so as to make adequate preparation for clinical application

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However, these guidelines primarily focused on managing SCD during dental services rather than the impact of dental care on the improvement of SCD treatment outcomes, which differs from the regulatory standard in 411.15(i)(3)(i) that the dental services are inextricably linked to, and substantially related and integral to the clinical success of, other covered services

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Mem Inst Oswaldo Cruz 100(Suppl 1):1923

Mhedi Belkoniene, Jennifer Socquet, Denise Njemba-Freiburghaus & Cyril Pellaton