Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease
Alternatively, serine can be converted to 3-hydroxypyruvate via transamination of pyruvate catalyzed by alanineglyoxylate and serinepyruvate aminotransferase 2 (encoded by the AGXT2 gene)
Karp NA, Meehan TF, Morgan H, Mason JC, Blake A, Kurbatova N, et al
Hospitals' measure results for Centers for Disease Control and Prevention (CDC) Central Line-Associated Bloodstream Infection (CLABSI), Catheter-Associated Urinary Tract Infection (CAUTI), Colon and Abdominal Hysterectomy Surgical Site Infection (SSI), Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, and Clostridium difficile Infection (CDI) are derived from standardized infection ratios (SIRs) calculated with hospital surveillance data reported to the CDC's National Healthcare Safety Network (NHSN) for infections occurring between January 1, 2021 and December 31, 2021
Lelcu T, Bn AM, Dnil MD, Popoiu CM, Aburel OM, Arghirescu ST, Borza C, Muntean DM (2021) Assessment of platelet mitochondrial respiration in a pediatric population: a pilot study in healthy children and children with acute lymphoblastic leukemia
APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus
