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Systemic administration of the nonselective 5-HT2A receptor agonists DOI (1-[2,5-dimethoxy-4-iodophenyl]- 2-aminopropane) and DOM (1-[2,5-dimethoxy-4- methylphenyl]-2-aminopropane) has been shown to reduce SWS and REM sleep, and to augment wakefulness in the rat (47-49) (Table I)

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These gut symptoms can include pain and discomfort as well as bloating