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Consider the following: Addiction: Nicotine is addictive, and dependency can make it hard to quit

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Nicotine Tob Res 20:173182 Mathis C, Poussin C, Weisensee D, Gebel S, Hengstermann A, Sewer A, Belcastro V, Xiang Y, Ansari S, Wagner S, Hoeng J, Peitsch MC (2013) Human bronchial epithelial cells exposed in vitro to cigarette smoke at the airliquid interface resemble bronchial epithelium from human smokers