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Negative symptoms are one of the core symptoms of SCZ and are strongly associated with long-term morbidity and poor functional outcomes in patients 5,6

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The symptoms of tobacco withdrawal include physical and mental challenges that individuals face when they attempt to quit using tobacco products, according to an article by the Centers for Disease Control and Prevention titled 7 Common Withdrawal Symptoms. As the body adjusts to the absence of nicotine, these withdrawal symptoms manifest in various physical and mental distress and issues, making the cessation process uncomfortable and challenging

Dopamine, norepinephrine, serotonin, glutamate, aminobutyric acid (GABA) and opioid peptides are neurotransmitter systems influenced by nAChRs (58)

A majority of participants aged 1824 years reported frequent use (150