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Hypoxia may produce poorer outcomes from radiation therapy and immunotherapy How your body processes chemotherapy drugs to make them less effective Smoking causes many types of cancers including lung, larynx (voice box), mouth, esophagus, throat, bladder, kidney, liver, stomach, pancreas, colon and rectum, and cervix, as well as acute myeloid leukemia If you have had or will receive radiation therapy, the combination of smoking and radiation therapy dramatically increases your lung cancer risk