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In the absence of a drug pretreatment, there are no age differences in the acquisition of cocaine self-administration ( Treatment with 5-HT 1A R antagonists during behavioral testing eliminates fluoxetine and nicotine pretreatment effects on quinpirole locomotion and cocaine reinforcement

But it wasn't a runaway success until the 1920s, when it was pitched as a solution for "chronic halitosis" a then obscure medical term for bad breath

Effects of smoking intensity ad cessation on inflammatory markers in a larger cohort of active smokers