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23 A sample of 879 was estimated via StatCal function of EpiInfo by utilizing the Unmatched Cohort and Cross-section Studies option according to the following parameters: Assuming 95% two-sided confidence level, power of 80%, exposure ratio of 2, the proportion of outcome in unexposed of 10.7%, and proportions of outcome in exposed of 20.6% and an OR of 2.16

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Further studies, perhaps using animal models, are needed to analyze the exact effect of smoking on each disease separately